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T1 - Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes N2 - Considerable evidence suggests that skeletal muscle insulin resistance is an inherent feature of type 2 diabetes and contributes to the pathogenesis of the disease.

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Insulin resistance is also an established independent risk factor for vascular disease, including stroke and myocardial infarction, and partly explains the association between diabetes and increased risk for these diseases Dandona says pioglitazone is currently used to treat patients with Type 2 diabetes.

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